Search results for " IIA"
showing 6 items of 6 documents
A new PCSK9 gene promoter variant affects gene expression and causes autosomal dominant hypercholesterolemia.
2008
Autosomal dominant hypercholesterolemia (ADH) is a genetic disorder characterized by increased low-density lipoprotein (LDL)-cholesterol levels, leading to high risk of premature cardiovascular disease. More than 900 mutations in LDL receptor, six in APOB and 10 in PCSK9 have been identified as a cause of the disease in different populations. All known mutations in PCSK9 causing hypercholesterolemia produce an increase in the enzymatic activity of this protease. Up to now, there are data about the implication of PCSK9 in ADH in a low number of populations, not including a Spanish population.The objective of the study was to study the prevalence of PCSK9 mutations in ADH Spanish population.W…
Internal audit professional principles and academic literature over the last decade: is there a gap to bridge
2022
The Institute of Internal Auditors (IIA) has defined the ethical principles internal auditors must adhere to, allowing them to create a common understanding of ethical behaviour within their profession, thereby promoting ethical culture. This paper aims to analyse the role of these principles in the main branches of internal audit research over the last decade. We examine the most important articles published in this field and categorise them into seven main strands. We assess the extent to which these strands focus on the IIA ethical principles, aiming to identify research gaps in the extant literature. Our findings show that the literature dealing with ethical principles in the recruitmen…
Oh, wait, O8 de Sitter may be unstable!
2021
We analyze the stability of four-dimensional de Sitter vacua constructed by compactifying massive Type IIA supergravity in the presence of two O8 sources [1]. When embedded in String Theory the first source has a clear interpretation as an O8$_-$ plane, but the second one could correspond to either an O8$_+$ plane or to an O8$_-$ plane with 16 D8-branes on top. We find that this latter solution has a tachyonic instability, corresponding to the D8-branes moving away from the O8$_-$ plane. We comment on the possible ways of distinguishing between these sources.
The Cerebral Thrombin System Is Activated after Intracerebral Hemorrhage and Contributes to Secondary Lesion Growth and Poor Neurological Outcome in …
2020
With increasing evidence for the existence of a cerebral thrombin system, coagulation factor IIa (thrombin) is suspected to influence the pathogenesis of secondary injury progression after intracerebral hemorrhage (ICH). We hypothesized that mechanisms associated with local volume expansion after ICH, rather than blood constituents, activate the cerebral thrombin system and are responsible for detrimental neurological outcome. To test this hypothesis, we examine the local thrombin expression after ICH in a C57BL/6N mouse model in the presence and absence of blood constituents. ICH was established using stereotaxic orthotopic injection of utologous blood (
Cargamentos de conservas de pescado béticas en el Mediterráneo Occidental durante la época Julio-Claudia
2023
A lo largo del Alto Imperio, la ciudad de Roma cuenta con aproximadamente un millón de habitantes, población que no igualará ninguna otra ciudad europea hasta el Londres del siglo XVIII, ni ninguna otra ciudad mediterránea hasta el Estambul del siglo XX. Con el fin de preservar su estabilidad, el Estado ha de atender tanto a las necesidades alimenticias de la megalópolis, como a las de las de las legiones diseminadas en las fronteras del Imperio. En este contexto, las provincias romanas como la Bética (actual Andalucía grosso modo) contribuyeron al aprovisionamiento alimenticio de la plebs y el ejército, implicando en ello numerosos barcos para la rápida y eficiente exportación de sus biene…